Phospho-P38 (Thr180/Tyr182) Polyclonal Antibody

Product Specifications

Background

MAPK14 (mitogen-activated protein kinase 14) is also named as SAPK2A, p38MAPK, CSBP1, RK, p38, EXIP, Mxi2, CSBP2, PRKM14, PRKM15, CSPB1, p38ALPHA and belongs to the MAP kinase subfamily. MAPK14-signaling is a central pathway for the integration of instructive signals in dendritic cells for T (H) 17 differentiation and inflammation (PMID:22231518) . It plays an important role in the regulation of hematopoietic stem cellself-renewal in vitro and inhibition of MAPK14 activation with a small molecule inhibitor may represent a novel approach to promote ex vivo expansion of hematopoietic stem cell (PMID:21198398) . This protein has 4 isoforms produced by alternative splicing.

Abbreviation

P38 (phospho Thr180/Tyr182)

UniProt

Q16539

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human p38 around the phosphorylation site of Thr180/Tyr182

Target

CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP 1; CSBP 2; CSBP; CSBP1; CSBP2; CSPB1; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX interacting protein 2; MAX-interacting protein 2; Mitogen Activated Protein Kinase 14; Mitogen activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MK14; Mxi 2; MXI2; p38 ALPHA; p38; p38 MAP kinase; p38 MAPK; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK2A

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Immunology; Signal Transduction

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:200

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

41kDa

Observed Molecular Weight

38kDa

Citation 01

https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-023-01803-8

Citation 02

https://onlinelibrary.wiley.com/doi/abs/10.1111/cpr.13351

Citation 03

https://www.sciencedirect.com/science/article/pii/S0753332223000823

Citation 04

https://www.mdpi.com/1281194

Citation 05

https://link.springer.com/article/10.1007/s12079-022-00703-0

Citation 06

https://link.springer.com/article/10.1186/s12935-022-02503-3

Citation 07

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364650/

Citation 08

https://www.mdpi.com/2076-3921/9/1/37/htm

Citation 09

https://pubs.acs.org/doi/abs/10.1021/acs.jafc.8b07227

Citation 10

https://www.sciencedirect.com/science/article/pii/S1567576918312372

Citation 11

https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14041

Citation 12

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201345/

Isotype

IgG

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