Phospho-HDAC5 (Ser498) Polyclonal Antibody
Product Specifications
Background
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
Abbreviation
HDAC5 (phospho Ser498)
UniProt
Q9UQL6
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser498
Target
Antigen NY CO 9; Antigen NY-CO-9; HD5; HDAC 5; HDAC5; HDAC5; Histone deacetylase 5; NY CO 9
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC-p; IF
Field of Research
Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Stem Cells
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
122kDa
Observed Molecular Weight
122kDa
Isotype
IgG
Available Sizes
Curated Selection
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