Irpagratinib
Irpagratinib (ABSK011) is an orally active FGFR4 inhibitor (IC50[1][2].
Product Specifications
CAS Number
2230974-62-4
Product Name Alternative
ABSK011
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/irpagratinib.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C(OC)=CC(OC)=C1F)=C1C2=CC(C=N3)=C(C(N4CC(C)(C4)OC)=N2)N=C3N[C@H]5[C@H](CCOC5)NC(C=C)=O
Molecular Formula
C28H32F2N6O5
Molecular Weight
570.59
References & Citations
[1]Chen Z. Abstract LB-272: Discovery and characterization of a novel FGFR4 Inhibitor for the treatment of hepatocellular carcinoma[J]. Cancer Research, 2018, 78 (13_Supplement) : LB-272-LB-272.|[2]Zhang N, et al. Selective FGFR4 inhibitor Irpagratinib (ABSK011) exhibits broad synergistic and combinatory anti-tumor effects with other therapeutic agents in preclinical HCC models]. Cancer Research, 2024, 84 (6_Supplement) : 1228-1228.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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