CITED4 Polyclonal Antibody

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.

AU019445; AW742964; Cbp/p300 interacting transactivator 4; cbp/p300 interacting transactivator; with glu/asp rich carboxy terminal domain; 4; Cbp/p300-interacting transactivator 4; CITE4; Cited4; MRG 2; MRG-2; Mrg2; MSG1 related protein 2; MSG1-related protein 2; Transcriptional co-activator 4