PTEN Polyclonal Antibody
Product Specifications
Background
PTEN (also designated MMAC1), products of tumor suppressor genes, are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors, such as brain, breast, kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.
Abbreviation
PTEN
UniProt
P60484
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human PTEN
Target
10q23del; BZS; DEC; GLM2; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatase and tensin like protein; Phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Pten; PTEN; PTEN1; TEP1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction
Purification
Antigen affinity purification
Concentration
0.9 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:20-1:100
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
47 kDa
Observed Molecular Weight
Refer to figures
Citation 01
https://www.sciencedirect.com/science/article/pii/S0168822722008804
Isotype
IgG
Available Sizes
Curated Selection
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