SAV1 Polyclonal Antibody

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1) -associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

1700040G09Rik;45 kDa WW domain protein; hWW 45; hWW45; Protein salvador homolog 1; salvador family WW domain containing protein 1; salvador homolog 1 (Drosophila) ; Salvador homolog 1; Salvador; Drosophila; homolog of; SAV 1; SAV; SAV1; SAV1; WW 45; WW domain containing; WW domain-containing adaptor 45; WW domain-containing protein; 45-KD; WW45; WW45 protein; WWP 4; WWP4