SC75741
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65[1]. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins[2].
Product Specifications
CAS Number
913822-46-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Influenza Virus; NF-κB
Type
Reference compound
Related Pathways
Anti-infection; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/sc75741.html
Purity
99.51
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(C=CC(C(C2=CC=CC=C2)=O)=C3)=C3N1)C4=CSC(C(CC5)CCN5C6=NC=NC7=C6SC=C7)=N4
Molecular Formula
C29H23N7O2S2
Molecular Weight
565.67
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RelA/p65
Available Sizes
Frequently Asked Questions
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