RNF111 Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Abbreviation
RNF111
UniProt
Q6ZNA4
Host
Rabbit
Reactivity
Human
Immunogen
Fusion protein of human RNF111
Target
ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; E3 ubiquitin-protein ligase Arkadia; FLJ38008; RING finger protein 111; RN111; RNF 111; RNF111
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cell Biology; Signal transduction
Purification
Antigen affinity purification
Concentration
0.84 mg/mL
Dilution
IHC 1:50-1:300
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB2259-100 1x 100 µL
Protein Tyrosine Phosphatase, non-receptor type 6 (CPTC-PTPN6-2), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
