PHF21A Polyclonal Antibody
Product Specifications
Background
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.
Abbreviation
PHF21A
UniProt
Q96BD5
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Fusion protein of human PHF21A
Target
BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa) ; KIAA1696; PF21A; PHD finger protein 21A; PHF21A
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Epigenetics and Nuclear Signaling; Neuroscience
Purification
Antigen affinity purification
Concentration
0.6 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:40-1:200
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
75 kDa
Observed Molecular Weight
Refer to figures
Isotype
IgG
Available Sizes
Frequently Asked Questions
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