Phenyl-glutarimide 4'-oxyacetic acid
Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy[1].
Product Specifications
CAS Number
2782024-58-0
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/phenyl-glutarimide-4-oxyacetic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(COC1=CC=C(C2C(NC(CC2)=O)=O)C=C1)O
Molecular Formula
C13H13NO5
Molecular Weight
263.25
References & Citations
[1]Min J, et al. Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew Chem Int Ed Engl. 2021 Dec 13;60 (51) :26663-26670.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Frequently Asked Questions
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