SLC7A11 Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Abbreviation
SLC7A11
UniProt
Q9UPY5
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human SLC7A11
Target
Amino acid transport system xc xCT; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Calcium channel blocker resistance protein CCBR1; CCBR1; Cysteine/glutamate transporter; Cystine/glutamate transporter; OTTHUMP00000164578; SLC7A11; Solute carrier family 7 (anionic amino acid transporter light chain; xc- system) ; member 11; solute carrier family 7; Solute carrier family 7 member 11; Solute carrier family 7; (cationic amino acid transporter; y+ system) member 11; SYSTEM Xc (-) TRANSPORTER-RELATED PROTEIN; xCT; XCT
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cell biology; Metabolism; Signal transduction
Purification
Affinity purification
Concentration
0.4 mg/mL
Dilution
IHC 1:20-100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
55 kDa
Isotype
IgG
Available Sizes
Curated Selection
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