TTI1 Polyclonal Antibody
Product Specifications
Background
Regulator of the DNA damage response (DDR) . Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC) . Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Abbreviation
TTI1
UniProt
O43156
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human TTI1
Target
Smg-10; KIAA0406
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cell biology; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
1.2 mg/mL
Dilution
IHC 1:30-150
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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