NPHS2 Polyclonal Antibody
Product Specifications
Background
This gene encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN) . SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined.
Abbreviation
NPHS2
UniProt
Q9NP85
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human NPHS2
Target
Nephrosis 2; idiopathic; steroid resistant (podocin) ; nephrosis 2; idiopathic; steroid resistant; NPHS2; NPHS2 gene; PDCN; PODO; Podocin; SRN1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cell biology; Signal transduction; Tags and Cell markers
Purification
Affinity purification
Concentration
1.4 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Citation 01
https://www.tandfonline.com/doi/abs/10.1080/1354750X.2022.2157489
Isotype
IgG
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