CD2AP Polyclonal Antibody
Product Specifications
Background
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
Abbreviation
CD2AP
UniProt
Q9Y5K6
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human CD2AP
Target
Adapter protein CMS; AL024079; C78928; Cas ligand with multiple SH3 domains; CD2 associated protein; CD2-associated protein; CD2AP; CD2AP; CMS; Mesenchyme to epithelium transition protein with SH3 domains 1; METS 1; Mets1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal transduction
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
WB 1:1000-1:5000; IHC 1:100-1:300
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
71kDa
Isotype
IgG
Available Sizes
Frequently Asked Questions
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