NUAK1 Polyclonal Antibody
Product Specifications
Background
NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5 (ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Abbreviation
NUAK1
UniProt
O60285
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human NUAK1
Target
AMP activated protein kinase family member 5; AMPK related protein kinase 5; AMPK-related protein kinase 5; NUAK family SNF1 like kinase; NUAK family SNF1-like kinase 1; Nuak1; NUAK1; Omphalocele kinase 1; Probable serine/threonine protein kinase KIAA0537
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Signal Transduction
Purification
Affinity purification
Concentration
1.4 mg/mL
Dilution
IHC 1:100-1:300
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG
Available Sizes
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