Actinobolin
Actinobolin ((+) -Actinobolin) is an antibiotic, that inhibits protein synthesis by targeting bacterial and eukaryotic ribosomes. Actinobolin inhibits Mycobacterium smegmatis, Escherichia coli and rabbit reticulocyte lysate (RRL) with an IC50 of 19.2, 27.9, and 288 μmol/L, respectively[1].
Product Specifications
CAS Number
24397-89-5
Product Name Alternative
(+) -Actinobolin
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/actinobolin.html
Smiles
C[C@H](N)C(N[C@@H]1[C@@]2([H])C(C(O[C@@H]1C)=O)=C(C[C@H]([C@@H]2O)O)O)=O
Molecular Formula
C13H20N2O6
Molecular Weight
300.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Tharra PR, et al., Short Synthesis of (+) -Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis. Angew Chem Int Ed Engl. 2022 Apr 19;61 (17) :e202116520.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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