LZTFL1 Polyclonal Antibody

This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.

5530402H04Rik;6130400H19Rik; AI414725; AW048545; BBS17; DKFZp686H2076; FLJ36386; Leucine zipper transcription factor like 1; Leucine zipper transcription factor like protein 1; Leucine zipper transcription factor-like protein 1; LZTFL 1; Lztfl1; Lztfl1 leucine zipper transcription factor-like 1; LZTL1; MGC106871; MGC108960; Putative uncharacterized protein DKFZp686H2076