ATXN1 Polyclonal Antibody
Product Specifications
Background
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions.
Abbreviation
ATXN1
UniProt
P54253
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human ATXN1
Target
Alternative ataxin1; Ataxin-1; ATX1; ATX1; Atxn1; D6S504E; OTTHUMP00000016065; SCA1; Spinocerebellar ataxia type 1 protein
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Epigenetics and Nuclear Signaling; Neuroscience
Purification
Affinity purification
Concentration
0.3 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
87kDa
Isotype
IgG
Available Sizes
Curated Selection
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