ASCC1 Polyclonal Antibody

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF) . The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Activating signal cointegrator 1 complex subunit 1; ASC-1 complex subunit p50; ASC1 complex subunit p50; ASC1p50; ASCC1; ASCC1; CGI 18; RP11-150D20.4; Trip4 complex subunit p50