Anti-Piccolo Antibody
Rabbit Polyclonal Antibody specific to Piccolo
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Anti-Piccolo Rabbit Polyclonal Antibody
UniProt
Q9Y6VO
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Full-length human protein (accession no. BC001304.1)
Target
Piccolo
Clonality
Polyclonal
Type
Antibody
Applications
WB, ELISA
Field of Research
Neuroscience
Purification Method
Purified by Protein G affinity chromatography
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Format
Purified
Form
Liquid
Buffer
Phosphate Buffered Saline
Additionnal Information
Immunoblotting: use at 10ug/ml. A band of ~550kDa is detected
<br><br>ELISA: use at 1-10ug/ml with Piccolo on the solid phase.
<br><br>Positive control: Rat brain tissue lysate
<br><br>These are recommended concentrations
<br><br>End user should determine optimal concentrations for their applications.
Storage Conditions
This antibody is stable for at least one (1) year at -20°C.
Specificity
This antibody recognizes human, mouse, and rat Piccolo isoforms (other species not tested). It does not cross-react with Bassoon.
Formulation
PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.
Buffer pH
pH 7.4
Target Background
Piccolo is a novel component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release. Piccolo is a multidomain zinc finger protein structurally related to Bassoon, another PCM protein. Both proteins share components of glutamatergic and GABAergic CNS synapses. Piccolo zinc fingers interact with the dual prenylated rab3A and VAMP2/Synaptobrevin II receptor PRA1. Piccolo is involved in endo- and exocytosis of synaptic vesicles and has been shown to interfere with clathrin- mediated endocytosis by binding to the F- actin and dynamin binding protein Abp1.
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