ALKBH2 Polyclonal Antibody
Product Specifications
Background
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro) . Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Abbreviation
ALKBH2
UniProt
Q6NS38
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant protein of human ALKBH2
Target
2OG Fe (II) oxy DC1;9530023G02; ABH 2; ABH2; alkB alkylation repair homolog 2; ALKB2; ALKBH2 alkB; ALKBH2; Alkylated DNA repair protein alkB homolog; Alkylated DNA repair protein alkB homolog 2; Alkylation repair homolog 2; Alpha ketoglutarate dependent dioxygenase alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; AU016977; DNA oxidative demethylase ALKBH2; EC 1.14.11.; FLJ99103; hABH2; mABH2; MGC90512; Oxy DC1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
0.4 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
29kDa
Isotype
IgG
Available Sizes
Curated Selection
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