HDAC8 Polyclonal Antibody

Product Specifications

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors.

Abbreviation

HDAC8

UniProt

Q9BY41

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human HDAC8

Target

CDA07; CDLS5; HD 8; HD8; HDAC 8; Hdac8; HDAC8; HDACL 1; HDACL1; Histone deacetylase 8; Histone deacetylase like 1; MRXS6; RPD 3; RPD3; WTS

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Stem Cells

Purification

Affinity purification

Concentration

0.7 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

42kDa

Citation 01

https://www.nature.com/articles/s41419-022-04901-x

Isotype

IgG

Available Sizes

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