CASP3 Polyclonal Antibody

Product Specifications

Background

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Abbreviation

CASP3

UniProt

P42574

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human CASP3

Target

A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cell Biology; Metabolism; Neuroscience

Purification

Affinity purification

Concentration

0.5 mg/mL

Dilution

WB 1:200-1:1000; IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

32kDa

Citation 01

https://www.sciencedirect.com/science/article/pii/S1382668922001739

Citation 02

https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-022-00747-3

Citation 03

https://europepmc.org/article/pmc/pmc8333701?javascript_support=no

Citation 04

https://www.sciencedirect.com/science/article/pii/S0300483X18303937

Citation 05

https://link.springer.com/article/10.1007/s12011-018-1535-3

Citation 06

https://www.sciencedirect.com/science/article/pii/S2666027X22000093

Isotype

IgG

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS1218121-01 0.02 mg (E-Coli)

Recombinant Pseudomonas putida Ferrochelatase (hemH)

Ask

View Details

MBS1218121-02 0.02 mg (Yeast)

Recombinant Pseudomonas putida Ferrochelatase (hemH)

Ask

View Details

MBS1218121-03 0.1 mg (E-Coli)

Recombinant Pseudomonas putida Ferrochelatase (hemH)

Ask

View Details

MBS1218121-04 0.1 mg (Yeast)

Recombinant Pseudomonas putida Ferrochelatase (hemH)

Ask

View Details

MBS1218121-05 0.02 mg (Baculovirus)

Recombinant Pseudomonas putida Ferrochelatase (hemH)

Ask

View Details

MBS1218121-06 0.02 mg (Mammalian-Cell)

Recombinant Pseudomonas putida Ferrochelatase (hemH)

Ask

View Details