BAX Polyclonal Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Abbreviation

BAX

UniProt

Q07812

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human BAX

Target

Apoptosis regulator BAX; BAX; Bax-protein; BAX; BAXA; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2 associated X protein omega; BCL2 associated X protein transcript variant delta2; Bcl2-L-4; BCL2L4; membrane isoform alpha

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cell Biology; Metabolism

Purification

Affinity purification

Concentration

0.2 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:25-1:100

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

21kDa

Citation 01

https://www.mdpi.com/1806946

Citation 02

https://www.sciencedirect.com/science/article/pii/S0753332220302663

Citation 03

https://www.sciencedirect.com/science/article/pii/S0024320522002600

Citation 04

https://link.springer.com/content/pdf/10.1007/s13311-019-00803-7.pdf

Citation 05

https://link.springer.com/article/10.1186/s12902-022-01143-y

Citation 06

https://www.sciencedirect.com/science/article/pii/S0300483X18303937

Citation 07

https://link.springer.com/article/10.1007/s10895-023-03180-9

Citation 08

https://www.sciencedirect.com/science/article/pii/S0006291X19321874

Citation 09

https://link.springer.com/article/10.1007/s10123-018-00051-3

Citation 10

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106821/

Isotype

IgG

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