DIO2 Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3) . It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Abbreviation
DIO2
UniProt
Q92813
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human DIO2
Target
5DII; D2; Deiodinase; iodothyronine; type II; DIO2; DIOII; EC 1.97.1.10; IOD2; ITDI2; SelY; Thyroxine deiodinase; type II; TXDI2; Type 2 DI; Type 2 iodothyronine deiodinase; Type II 5' deiodinase; Type II iodothyronine deiodinase; Type-II 5''-deiodinase
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Metabolism; Neuroscience; Signal Transduction
Purification
Affinity purification
Concentration
0.9 mg/mL
Dilution
IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Citation 01
https://www.frontiersin.org/articles/10.3389/fonc.2020.01771/full?report=reader
Isotype
IgG
Available Sizes
Curated Selection
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