MYSM1 Polyclonal Antibody
Product Specifications
Background
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation.Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones
Abbreviation
MYSM1
UniProt
Q5VVJ2
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human MYSM1
Target
2A-DUB;2ADUB; Histone H2A deubiquitinase; Histone H2A deubiquitinase MYSM1; KIAA1915; Myb like SWIRM and MPN domains 1; Myb like; SWIRM and MPN domain containing protein; Myb like; SWIRM and MPN domains 1; Myb-like; Myb-like; SWIRM and MPN domains 1; MYSM 1; mysm1; MYSM1 Myb-like; SWIRM and MPN domains 1; MYSM1; RP4-592A1.1; SWIRM and MPN domain-containing protein 1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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