CHRNA7 Polyclonal Antibody

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A) . Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

7nAChR; a7 nicotinic acetylcholine receptor; acetylcholine receptor; neuronal nicotinic; alpha-7 subunit; ACHA7; AChR; Acra7; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha7; cholinergic receptor; neuronal nicotinic; alpha polypeptide 7; cholinergic receptor; nicotinic; alpha 7 (neuronal) ; cholinergic receptor; nicotinic; alpha 7; cholinergic receptor; nicotinic; alpha polypeptide 7; CHRNA7; CHRNA7-2; NACHRA7; neuronal acetylcholine receptor protein; alpha-7 chain; Neuronal acetylcholine receptor subunit alpha-7