GRPR Polyclonal Antibody
Product Specifications
Background
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Abbreviation
GRPR
UniProt
P30550
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human GRPR
Target
BB2; Bombesin BB2 receptor; bombesin receptor 2; Gastrin Releasing Peptide Receptor; Gastrin-releasing peptide receptor; GRP preferring bombesin receptor; GRP R; GRP-preferring bombesin receptor; GRP-R; Grp/bombesin receptor; Grpr; GRPR
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Neuroscience; Signal Transduction
Purification
Affinity purification
Concentration
1.1 mg/mL
Dilution
WB 1:200-1:1000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
43kDa
Isotype
IgG
Available Sizes
Curated Selection
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