TRAP-6

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].

Product Specifications

CAS Number

[141136-83-6]

Product Name Alternative

PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Protease Activated Receptor (PAR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/TRAP-6.html

Purity

99.98

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(N)=O)=O)=O)=O)[C@@H](NC([C@@H](N)CO)=O)CC1=CC=CC=C1

Molecular Formula

C34H56N10O9

Molecular Weight

748.87

Precautions

H302, H315, H319, H335

References & Citations

[1]Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103 (6) :879-87.|[2]Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82 (1) :103-6.|[3]Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349 (2-3) :237-43.