TNFRSF11B Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Abbreviation
TNFRSF11B
UniProt
O00300
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human TNFRSF11B
Target
MGC29565; OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; PDB5; TNF receptor superfamily member 11b; TNFRSF 11B; TNFRSF11B; TR 1; TR1; TR11B; Tumor necrosis factor receptor superfamily member 11B
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cardiovascular; Metabolism; Immunology; Signal Transduction
Purification
Affinity purification
Concentration
0.3 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
46kDa
Citation 01
https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.14218
Citation 02
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367655/
Isotype
IgG
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