M40

This small molecule is a potent, non-selective galanin receptor antagonist with Ki values of 1.82 nM (GAL1) and 5.1 nM (GAL2) . It blocks galanin-mediated effects, including the attenuation of fluoxetine's antidepressant action and the inhibition of galanin-induced feeding behavior in vivo, making it a valuable tool for neuropharmacology and behavioral studies.