GSK1702934A

GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3[1][2].

Product Specifications

CAS Number

[924377-85-5]

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gsk1702934a.html

Purity

99.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC2=CC=CC=C2N1C3CCN(C(C4=CC(CCCCC5)=C5S4)=O)CC3

Molecular Formula

C22H25N3O2S

Molecular Weight

395.52

References & Citations

[1]de la Cruz GG, et al. Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core. Synlett. 2017 Apr;28 (6) :695-700.|[2]Doleschal B, et al. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc Res. 2015 Apr 1;106 (1) :163-73.|[3]Xu, X., et al. Schnackenberg, C. G. Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists. Biophysical Journal, 2013. 104 (2), 454a.