Thiocoraline

Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms[1].

Product Specifications

CAS Number

[173046-02-1]

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thiocoraline.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N(C([C@@]1([H])N(C(CNC([C@@H](CSC([C@@H](N(C([C@@](CSSC1)([H])N(C(CNC2=O)=O)C)=O)C)CSC)=O)NC(C3=NC4=C(C=CC=C4)C=C3O)=O)=O)=O)C)=O)C)CSC)SC[C@H]2NC(C5=NC6=C(C=CC=C6)C=C5O)=O

Molecular Formula

C48H56N10O12S6

Molecular Weight

1157.41

References & Citations

[1]Romero F, et al. Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities. J Antibiot (Tokyo) . 1997 Sep;50 (9) :734-7.