Thiocoraline
Product Specifications
UNSPSC Description
Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms[1].
Target Antigen
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thiocoraline.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N(C([C@@]1([H])N(C(CNC([C@@H](CSC([C@@H](N(C([C@@](CSSC1)([H])N(C(CNC2=O)=O)C)=O)C)CSC)=O)NC(C3=NC4=C(C=CC=C4)C=C3O)=O)=O)=O)C)=O)C)CSC)SC[C@H]2NC(C5=NC6=C(C=CC=C6)C=C5O)=O
Molecular Weight
1157.41
References & Citations
[1]Romero F, et al. Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities. J Antibiot (Tokyo). 1997 Sep;50(9):734-7.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3116/Thiocoraline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3116/
Clinical Information
No Development Reported
CAS Number
173046-02-1
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