Ganoderic acid DM

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

Product Specifications

CAS Number

173075-45-1

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; PI3K

Type

Natural Products

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ganoderic-acid-dm.html

Purity

99.9

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@]12C3=C(CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C)/C(O)=O)C)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC3=O)C

Molecular Formula

C30H44O4

Molecular Weight

468.67

Precautions

H315, H319, H335

References & Citations

[1]Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83 (2) :408-14.|[2]Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602 (1) :1-7.|[3]Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.