ML388

ML388 is a potent and selective hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with an IC50 of 34 nM. ML388 induces PGE2 production in A549 cells and LNCaP prostate cancer cells[1].

Product Specifications

CAS Number

[1537192-31-6]

UNSPSC

12352005

Target

PGE synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ml388.html

Smiles

CC1=CC=C(C=C1)N2C(C)=C(C=C2C)C3=NN=C4N3CCCCC4

Molecular Formula

C20H24N4

Molecular Weight

320.43

References & Citations

[1]Damien Y. Duveau, et al. Discovery of two small molecule inhibitors, ML387 and ML388, of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase.