CDK/HDAC-IN-4
CDK/HDAC-IN-4 is a high selective dual cyclin-dependent kinase (CDK) /histone deacetylase (HDAC) inhibitor with IC50 values of 88.4 and 168.9 nM, respectively. CDK/HDAC-IN-4 exhibits antiproliferative capacities against hematological and solid tumor cells. CDK/HDAC-IN-4 also induces MV-4-11 cell Apoptosis and S cell cycle arrests. CDK/HDAC-IN-4 possesses a significant antitumor potency in the MV-4-11 xenograft model[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; CDK; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk-hdac-in-4.html
Smiles
ClC1=CN=C(C=C1C2=CC=CC(NCC3(CCOCC3)C#N)=N2)NC4=CN(N=C4)CC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O
Molecular Formula
C34H32ClN9O2
Molecular Weight
634.13
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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