SARS-CoV-2-IN-96

SARS-CoV-2-IN-96 (compound 12b) is an inhibitor of HCoV-OC43 (EC50= 97 nM) and SARS-CoV-2 (EC50= 45 nM) and low cytotoxicity (CC50> 10 μM) in Huh7 cells[1].

Product Specifications

UNSPSC

12352211

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-2-in-96.html

Smiles

CC1(C)[C@@]2([H])CN(C([C@H](C(C)(C)C)NC(C(F)(F)F)=O)=O)[C@H](C(N[C@@H](C[C@@H]3CCNC3=O)/C=C/C(OC)=O)=O)[C@]21[H]

Molecular Formula

C26H37F3N4O6

Molecular Weight

558.59

References & Citations

[1]Wen Shen, et al. Discovery of the potent covalent inhibitor with an acrylate warhead for SARS-CoV-2 3CL protease. Bioorg Med Chem Lett. 2024 Nov 1:112:12994.