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RR-RJW100

RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease[1][2].

Product Specifications

UNSPSC

12352005

Target

Orphan Nuclear Receptor; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/rr-rjw100.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1CC[C@@]2(C(C3=CC=CC=C3)=C)C(C4=CC=CC=C4)=C(CCCCCC)C[C@@]12[H]

Molecular Formula

C28H34O

Molecular Weight

386.57

References & Citations

[1]Suzanne G Mays, et al. Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist. Sci Rep. 2020 Dec 17;10 (1) :22279.|[2]Alisa Lang, et al. The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators. J Med Chem. 2021 Dec 9;64 (23) :16956-16973.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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