EOAI3402143

EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5.

Product Specifications

CAS Number

[1699750-95-2]

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/EOAI3402143.html

Concentration

10mM

Purity

98.11

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC1=C(/C=C(C(NC(CCC)C2=CC=C(OCCN3CCOCC3)C=C2)=O)\C#N)N=C(Cl)C=C1

Molecular Formula

C25H28Cl2N4O3

Molecular Weight

503.42

Precautions

H301, H311, H331

References & Citations

[1]Potu H, et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. 2014 Jul 30;5 (14) :5559-69.|[2]Peterson LF, et al. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. 2015 Jun 4;125 (23) :3588-97.|[3]Pal A, et al. Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth. Neoplasia. 2018 Feb;20 (2) :152-164.