RIPK1-IN-7

RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model[1].

Product Specifications

CAS Number

[2300982-44-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ripk1-in-7.html

Concentration

10mM

Purity

98.56

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

NC1=C2C(N(CC)C=C2C3=CC(CCN4C(CC5=CC=CC(OC(F)(F)F)=C5)=O)=C4C=C3)=NC=N1

Molecular Formula

C25H22F3N5O2

Molecular Weight

481.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Li Y, et al. Identification of 5- (2,3-Dihydro-1 H-indol-5-yl) -7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. J Med Chem. 2018 Dec 27;61 (24) :11398-11414.