APC Anti-Human CD22 Antibody[HIB22]
Product Specifications
Background
CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup) . CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.
Abbreviation
CD22
Gene ID
933
UniProt
P20273
Host
Mouse
Reactivity
Human
Target
Siglec2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; CD22; Cd22; Lyb-8; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14
Clonality
Monoclonal
Clone
HIB22
Conjugation
APC
Applications
FCM
Field of Research
Immunology
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Mouse IgG1, κ
Available Sizes
Frequently Asked Questions
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