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PE/Cyanine7 Anti-Mouse IL-17A Antibody[17F3]

Product Specifications

Background

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-17A in vivo.

Abbreviation

IL-17A

Gene ID

16171

UniProt

Q62386

Host

Mouse

Reactivity

Mouse

Target

Ctla8; Il17a; Interleukin-17A

Clonality

Monoclonal

Clone

17F3

Conjugation

PE/Cyanine 7

Applications

ICFCM

Field of Research

Cell Biology; Immunology; Neuroinflammation; Neuroscience

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Product Datasheet

https://789.bio/ea/0gahah

Product MSDS

https://789.bio/eb/TWDKW1

Citation 01

https://www.sciencedirect.com/science/article/pii/S0141813025026649

Citation 02

https://www.sciencedirect.com/science/article/pii/S0944711324001545

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ

Available Sizes

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