PE/Cyanine7 Anti-Mouse IL-17A Antibody[17F3]
Product Specifications
Background
The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-17A in vivo.
Abbreviation
IL-17A
Gene ID
16171
UniProt
Q62386
Host
Mouse
Reactivity
Mouse
Target
Ctla8; Il17a; Interleukin-17A
Clonality
Monoclonal
Clone
17F3
Conjugation
PE/Cyanine 7
Applications
ICFCM
Field of Research
Cell Biology; Immunology; Neuroinflammation; Neuroscience
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Citation 01
https://www.sciencedirect.com/science/article/pii/S0141813025026649
Citation 02
https://www.sciencedirect.com/science/article/pii/S0944711324001545
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Mouse IgG1, κ
Available Sizes
Curated Selection
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