FITC Anti-Human CD86 Antibody[IT2.2]

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Activation B7-2 antigen; B7-2; B7.2; B70; BU63; CD28LG; CD28LG2; CD86; CTLA-4 Counter-Receptor B; CTLA-4 Counter-Receptor B7.2; ETC; ETC-1; Early T-cell costimulatory molecule; Early T-cell costimulatory molecule 1; FUN; FUN-1; LAB; LAB72; T-lymphocyte activation antigen C