FITC Anti-Human CD86 Antibody[IT2.2]
Product Specifications
Background
CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Abbreviation
CD86
Gene ID
942
UniProt
P42081
Host
Mouse
Reactivity
Human
Target
Activation B7-2 antigen; B7-2; B7.2; B70; BU63; CD28LG; CD28LG2; CD86; CTLA-4 Counter-Receptor B; CTLA-4 Counter-Receptor B7.2; ETC; ETC-1; Early T-cell costimulatory molecule; Early T-cell costimulatory molecule 1; FUN; FUN-1; LAB; LAB72; T-lymphocyte activation antigen C
Clonality
Monoclonal
Clone
IT2.2
Conjugation
FITC
Applications
FCM
Field of Research
Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Citation 01
https://www.sciencedirect.com/science/article/pii/S1385894723066639
Citation 02
https://www.hindawi.com/journals/bmri/2022/3946754/
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Mouse IgG2b, κ
Available Sizes
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