FITC Anti-Mouse Foxp3 Antibody[3G3]

Product Specifications

Background

FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25) . Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.

Abbreviation

Foxp3

Gene ID

50943;20371;317382

UniProt

Q99JB6

Host

Mouse

Reactivity

Mouse

Target

Forkhead box protein P3; Foxp3; IPEX; JM2

Clonality

Monoclonal

Clone

3G3

Conjugation

FITC

Applications

ICFCM

Field of Research

Immunology

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.nature.com/articles/s41563-024-02054-0

Citation 02

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c00392

Citation 03

https://www.sciencedirect.com/science/article/pii/S1385894724035204

Citation 04

https://www.sciencedirect.com/science/article/pii/S0142961225000158

Citation 05

https://www.sciencedirect.com/science/article/pii/S0168365925004365

Citation 06

https://www.nature.com/articles/s41419-022-05069-0

Citation 07

https://www.nature.com/articles/s41419-023-06408-5

Citation 08

https://link.springer.com/article/10.1007/s00262-024-03692-8

Citation 09

https://www.mdpi.com/1424-8247/18/1/67

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ

Available Sizes

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