Elab Fluor® 647 Anti-Human CD16 Antibody[3G8]
Product Specifications
Background
CD16 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD16 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD16 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD16 appears to be expressed later in the immune response than CD86. CD16 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Abbreviation
CD16
Gene ID
941
UniProt
P08637; O75015
Host
Mouse
Reactivity
Human; Rhesus; Cynomolgus
Target
Fc gamma receptor; Fc gamma receptor 3; FcγRIII
Clonality
Monoclonal
Clone
3G8
Conjugation
Elab Fluor®647
Applications
FCM
Field of Research
Immunology; Innate Immunity
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Citation 01
https://www.frontiersin.org/articles/10.3389/fcimb.2021.785166/full?utm_source=dlvr.it&utm_medium=twitter
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Mouse IgG1, κ
Available Sizes
Curated Selection
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