PE Anti-Mouse CD105 Antibody[MJ7/18]
Product Specifications
Background
CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.
Abbreviation
CD105
Gene ID
13805
UniProt
Q63961
Host
Rat
Reactivity
Mouse
Target
END; Endoglin; Eng
Clonality
Monoclonal
Clone
MJ7/18
Conjugation
PE
Applications
FCM
Field of Research
Angiogenesis; Cell Adhesion; Cell Biology; Immunology; Stem Cells
Concentration
0.2 mg/mL
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Product Datasheet
https://789.bio/ea/dilu18
Product MSDS
https://789.bio/eb/D8erX5
Citation 01
https://www.mdpi.com/2073-4409/10/4/761
Recommended Usage
6
Isotype
Rat IgG2a, κ
Available Sizes
Curated Selection
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