Purified Anti-Human CD11a Antibody[R7-1]

CD11a is a 170-180 kD type I transmembrane glycoprotein also known as LFA-1α chain and integrin αL subunit. CD11a non-covalently associates with integrin β2 (CD18) to form LFA-1. It is expressed on all leukocytes, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. It is absent on non-hematopoietic tissues and platelets. CD11a plays a central role in leukocyte cell-cell interactions and is important in lymphocyte costimulation. CD11a/CD18 binds to ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50) .

LFA; Lymphocyte antigen; CD11A; LFA-1; LFA1A; ITGAL; LFA-1A; Ly-15; Lymphocyte antigen 15; Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A) ; Leukocyte function-associated molecule 1 alpha chain; integrin &alpha-L-L; LFA1