PE Anti-Mouse IL-17A Antibody[TC11-18H10.1]

Product Specifications

Background

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Abbreviation

IL-17A

Gene ID

16171

UniProt

Q62386

Host

Rat

Reactivity

Mouse

Target

CTLA-8; CTLA8; Cytotoxic T-lymphocyte-associated antigen 8; IL-17; IL-17A; Interleukin-17A

Clonality

Monoclonal

Clone

TC11-18H10.1

Conjugation

Applications

ICFCM

Field of Research

Cell Biology; Immunology; Neuroinflammation; Neuroscience

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00611-6

Citation 02

https://pmc.ncbi.nlm.nih.gov/articles/PMC11658117/

Citation 03

https://pubs.rsc.org/en/content/articlelanding/2025/fo/d4fo03966a

Citation 04

https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-024-00347-1

Citation 05

https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo03003e

Citation 06

https://www.mdpi.com/1422-0067/24/12/9922

Citation 07

https://www.sciencedirect.com/science/article/pii/S1567576923008135

Citation 08

https://www.sciencedirect.com/science/article/pii/S0006295223005506

Citation 09

https://www.dovepress.com/qinge-pills-ameliorates-osteoporosis-by-regulating-gut-microbiota-and--peer-reviewed-fulltext-article-JIR

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG1, κ

Available Sizes

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