Verbenalin

Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease[1][2][3][4][5].

Product Specifications

CAS Number

[548-37-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Amyloid-β; Bcl-2 Family; Caspase; Ferroptosis; SARS-CoV; Tau Protein

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/verbenalin.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CO[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@]3([H])[C@]1([H])C(C[C@@H]3C)=O)OC

Molecular Formula

C17H24O10

Molecular Weight

388.37

Precautions

H302, H315, H319

References & Citations

[1]Miao M, et al. Effects of verbenalin on prostatitis mouse model. Saudi J Biol Sci. 2016 Jan;23 (1) :S148-57.|[2]Cao L, et al. The protective role of verbenalin in rat model of focal cerebral ischemia reperfusion. Saudi J Biol Sci. 2018 Sep;25 (6) :1170-1177.|[3]Hafiza Salaha Mahrosh, et al. An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals. Environ Dev Sustain. 2021 Apr 3;1-14.|[4]Lim J, et al. Verbenalin Reduces Amyloid-Beta Peptide Generation in Cellular and Animal Models of Alzheimer's Disease. Molecules. 2022 Dec 8;27 (24) :8678.|[5]Dong J, et al. Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX/PPARα-mediated ferroptosis. J Ethnopharmacol. 2023 May 10;307:116227.